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7-(Substituted-phenyl)amino-5,8-quinazolinediones: Potent inhibitors of endothelium-dependent vasorelaxation

Title
7-(Substituted-phenyl)amino-5,8-quinazolinediones: Potent inhibitors of endothelium-dependent vasorelaxation
Authors
Ryu C.-K.Shin K.-H.Seo J.-H.Kim H.-J.
Ewha Authors
유충규김화정
SCOPUS Author ID
유충규scopus; 김화정scopus
Issue Date
2001
Journal Title
Medicinal Chemistry Research
ISSN
1054-2523JCR Link
Citation
vol. 10, no. 9, pp. 605 - 614
Indexed
SCIE; SCOPUS WOS scopus
Abstract
7-(Substituted-phenyl)amino-5,8-quinazolinediones (4) were synthesized by the substitution of 7-methoxy-5,8-quinazolinedione (5) with arylamines. All synthesized 5,8-quinazolinediones 4 showed a potent and efficacious inhibitory effect on the acetylcholine (ACh)-induced vasorelaxation of rat aorta with the endothelium. The quinones, at a low concentration of 0.1 μM, reduced the maximal response with an increase of EC50 values for ACh. The results indicate that quinones 4 are potent inhibitors of endothelium-dependent vasorelaxation.
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약학대학 > 약학과 > Journal papers
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