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Expression of glial cell line-derived neurotrophic factor (GDNF) in the developing human fetal brain

Title
Expression of glial cell line-derived neurotrophic factor (GDNF) in the developing human fetal brain
Authors
Koo H.Choi B.H.
Ewha Authors
구혜수
SCOPUS Author ID
구혜수scopus
Issue Date
2001
Journal Title
International Journal of Developmental Neuroscience
ISSN
0736-5748JCR Link
Citation
vol. 19, no. 6, pp. 549 - 558
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
GDNF expression was examined immunocytochemically in developing human fetal brains obtained from aborted fetuses ranging from 7 to 39 weeks in gestational age. At 7-8 weeks, strong immunoreactivity was noted within radial glial processes, glia limitans and choroid plexus of the telencephalic vesicle. By 10 weeks, ependymal cells, primitive matrix cells and early developing cortical plate neurons showed positive staining. By 15-16 weeks, migrating neurons in the subventricular and intermediate zones and in the cortical plate were strongly positive for GDNF. The glia limitans of the cerebral cortex and subependymal astrocytes remained positive at this time. As fetal age increased, GDNF expression shifted to neurons and glial cells in the deeper structures of the brain. The most prominent GDNF staining was observed in the cytoplasm and dendrites of Purkinje cells of the cerebellum by 25 weeks and thereafter. Pyramidal neurons of the CA1 region and granule cells of the dentate fascia of the hippocampus, neurons of the entorhinal cortex, and scattered neurons within the brain stem, medulla and spinal cord all showed strong GDNF staining by 25-35 weeks. Widespread GDNF expression in neuronal and non-neuronal cells with distinct developmental shifts suggests that GDNF may play a critical role in the survival, differentiation and maintenance of neurons at different stages of development in the developing human fetal brain. Copyright © 2001 ISDN. Elsevier Science Ltd.
DOI
10.1016/S0736-5748(01)00042-9
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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