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Iron tetrakis (N-methyl-4′-pyridyl) porphyrinato (FeTMPyP) is a potent scavenging antioxidant and an inhibitor of stimulant-induced NF-κB activation of RAW 264.7 macrophages

Title
Iron tetrakis (N-methyl-4′-pyridyl) porphyrinato (FeTMPyP) is a potent scavenging antioxidant and an inhibitor of stimulant-induced NF-κB activation of RAW 264.7 macrophages
Authors
Kang J.L.Lee H.S.Pack I.S.Leonard S.Castranova V.
Ewha Authors
이지희
SCOPUS Author ID
이지희scopus
Issue Date
2001
Journal Title
Journal of Toxicology and Environmental Health - Part A
ISSN
1528-7394JCR Link
Citation
vol. 64, no. 4, pp. 291 - 310
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Metalloporphyrins have been shown to be protective in oxidative stress models. However, the molecular basis for the antioxidative and antiinflammatory activities of iron tetrakis (N-methyl-4′-pyridyl) porphyrinato (FeTMPyP) is not known. The objective of this study was to determine whether FeTMPyP exhibited the ability to (1) scavenge reactive oxygen species (ROS), (2) inhibit the activation of nuclear factor kappa B (NF-κB), or (3) block the production of interleukin 1 (IL-1) in RAW 264.7 cultured macrophages. The results indicate that FeTMPyP is a potent scavenger of hydroxyl radicals and superoxide anion radicals, and an effective inhibitor of stimulant-induced NF-κB activation and IL-1 production by RAW 264.7 cells. Therefore, FeTMPyP may be a useful tool to investigate the molecular mechanisms involved in stimulant-induced signal pathways, and may possess therapeutic utility in diseases associated with overproduction of ROS.
DOI
10.1080/152873901316981295
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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