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Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure

Title
Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure
Authors
Che Y.Yu Y.-M.Han P.-L.Lee J.-K.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2001
Journal Title
Molecular Brain Research
ISSN
0169-328XJCR Link
Citation
vol. 94, no. 1-2, pp. 157 - 165
Indexed
SCOPUS WOS scopus
Abstract
Activation of p38 mitogen-activated protein kinase (p38 MAPK) has been implicated in pathological changes in inflammatory and apoptotic processes in various cell types including neurons. Here we report the delayed induction of p38 MAPKs in the brain of mice following kainic acid (KA)-induced seizure. The immunoreactivities of p38α and p38β MAPKs were markedly increased in the brain 4 days after KA administration, especially in the areas undergoing selective neuronal loss. In particular, p38β was dramatically increased in reactive astrocytes of CA3 and CA1 regions of hippocampus with its enriched localization in the nucleus of astrocytes. The induction of p38β was sustained for more than 10 days after KA-treatment. Pre-administration of the selective neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI), which suppressed the delayed neuronal death as well as astrogliosis in hippocampus of seizure-experienced animals, dramatically repressed the delayed induction of p38β MAPK in astrocytes. The repression was reversed by the co-injection with L-arginine (L-arg), a substrate for NOS, which coincided with the aggravation of neuronal death. Together, these data suggested a role of p38 MAPK signal pathway in delayed neuronal death and/or in reactive gliosis in mice with KA-induced seizure. © 2001 Elsevier Science B.V. All rights reserved.
DOI
10.1016/S0169-328X(01)00233-9
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일반대학원 > 뇌·인지과학과 > Journal papers
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