Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2016-08-28T11:08:46Z | - |
dc.date.available | 2016-08-28T11:08:46Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.other | OAK-814 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218853 | - |
dc.description.abstract | Small heat shock proteins have been implicated in playing a role in various cellular processes, including stress-induced cell death. In kainic acid (KA)-treated rat brain, the immunoreactivity of heat-shock protein 27 (HSP27) was markedly increased in glia cells of the limbic system. In the present study, we demonstrated that αB-crystallin, a member of the small heat-shock protein family, was strongly induced in reactive astrocytes in hippocampus after KA-induced seizure. The induction was localized mainly in the CA3 region of hippocampus, where massive neuronal loss occurred. We also demonstrated that the delayed induction of αB-crystallin and HSP27 immunoreactivities in the hippocampus of epileptic animals was repressed to the levels seen in control animals with preadministration of the selective nNOS inhibitor 7-nitroindazole (7-NI). This repression was reversed by coinjection of L-arginine, a substrate of NOS. Together, these data suggest a role for αB-crystallin and HSP27 in reactive gliosis and/or in delayed neuronal death proceeded after KA-induced seizure. © 2001 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.title | Delayed induction of αB-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 65 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 425 | - |
dc.relation.lastpage | 431 | - |
dc.relation.journaltitle | Journal of Neuroscience Research | - |
dc.identifier.doi | 10.1002/jnr.1170 | - |
dc.identifier.wosid | WOS:000170734500009 | - |
dc.identifier.scopusid | 2-s2.0-0035449165 | - |
dc.author.google | Che Y. | - |
dc.author.google | Piao C.S. | - |
dc.author.google | Han P.-L. | - |
dc.author.google | Lee J.-K. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |