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Delayed induction of αB-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain
- Title
- Delayed induction of αB-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain
- Authors
- Che Y.; Piao C.S.; Han P.-L.; Lee J.-K.
- Ewha Authors
- 한평림
- SCOPUS Author ID
- 한평림
- Issue Date
- 2001
- Journal Title
- Journal of Neuroscience Research
- ISSN
- 0360-4012
- Citation
- Journal of Neuroscience Research vol. 65, no. 5, pp. 425 - 431
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Small heat shock proteins have been implicated in playing a role in various cellular processes, including stress-induced cell death. In kainic acid (KA)-treated rat brain, the immunoreactivity of heat-shock protein 27 (HSP27) was markedly increased in glia cells of the limbic system. In the present study, we demonstrated that αB-crystallin, a member of the small heat-shock protein family, was strongly induced in reactive astrocytes in hippocampus after KA-induced seizure. The induction was localized mainly in the CA3 region of hippocampus, where massive neuronal loss occurred. We also demonstrated that the delayed induction of αB-crystallin and HSP27 immunoreactivities in the hippocampus of epileptic animals was repressed to the levels seen in control animals with preadministration of the selective nNOS inhibitor 7-nitroindazole (7-NI). This repression was reversed by coinjection of L-arginine, a substrate of NOS. Together, these data suggest a role for αB-crystallin and HSP27 in reactive gliosis and/or in delayed neuronal death proceeded after KA-induced seizure. © 2001 Wiley-Liss, Inc.
- DOI
- 10.1002/jnr.1170
- Appears in Collections:
- 일반대학원 > 뇌·인지과학과 > Journal papers
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