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Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1

Title
Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1
Authors
Kim H.-S.Hwang S.-L.Nah S.-Y.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2001
Journal Title
Pharmacological Research
ISSN
1043-6618JCR Link
Citation
vol. 43, no. 5, pp. 473 - 479
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABAA receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [3H]MK-801 binding, and the GABAA receptor bindings were analysed by using [3H]muscimol and [3H]flunitrazepam binding in rat brain slices. Rats were infused with ginsenoside Rc or Rg1 (10 μg/10 μl h-1, i.c.v.) for 7 days, through pre-implanted cannula using osmotic minipumps (Alzet, model 2ML). The levels of [3H]MK-801 binding were highly decreased in part of the parietal layers of the cortex and cingulated by ginsenoside Rc and Rg1. The levels of [3H]muscimol binding were strongly elevated in almost all regions of the frontal cortex by the treatment of ginsenoside Rc but decreased by ginsenoside Rg1. However, the [3H]flunitrazepam binding was not modulated by ginsenoside Rc or Rg1 infusion. These results suggest that prolonged infusion of ginsenosides could differentially modulate [3H]MK-801 and [3H]muscimol binding in a region-specific manner. © 2001 Academic Press.
DOI
10.1006/phrs.2001.0809
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의학전문대학원 > 의학과 > Journal papers
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