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Development of semi-empirical model for radiochemical reactions

Title
Development of semi-empirical model for radiochemical reactions
Authors
Lee R.J.Sun H.
Ewha Authors
서현숙이레나
SCOPUS Author ID
이레나scopus
Issue Date
2001
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 16, no. 3, pp. 283 - 289
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
A mathematical model, which represents the radio-chemical reactions in water, was developed to study the effect of the radio-chemical products on cell kiling. The five differential equations were solved using dose rate equation and cell survival as a function of dose was computed. The known chemical rate constants were taken from the literature and unknown constants were determined by curve fitting to an experimental data. Sensitivity studies were performed by varying the rate constants and showed that the yield of H-radical had little effect whereas the change in concentration of OH-radical and direct interaction resulted in significant change on cell survival. The sensitivity studies showed good agreement with the observed effects. In conclusion, we developed a mathematical model that could be used as a means for the estimation of radiation damage. Copyright © The Korean Academy of Medical Sciences.
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의학전문대학원 > 의학과 > Journal papers
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