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Inhaled nitric oxide down-regulates intrapulmonary nitric oxide production in lipopolysaccharide-induced acute lung injury

Title
Inhaled nitric oxide down-regulates intrapulmonary nitric oxide production in lipopolysaccharide-induced acute lung injury
Authors
Koh Y.Kang J.L.Park W.Pack I.S.Lee H.S.Kim M.J.Lim C.-M.
Ewha Authors
이지희
SCOPUS Author ID
이지희scopus
Issue Date
2001
Journal Title
Critical Care Medicine
ISSN
0090-3493JCR Link
Citation
vol. 29, no. 6, pp. 1169 - 1174
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: To examine whether inhaled nitric oxide (NO) affected the intrapulmonary production of NO, reactive oxygen species, and nuclear factor-κB in a lipopolysaccharide (LPS)-induced model of acute lung injury. Design: Prospective, randomized, laboratory study. Setting: Experimental laboratory at a biomedical institute. Subjects: Twenty male rabbits weighing 2.5-3.5 kg. Interventions: Saline or LPS (5 mg/kg of body weight) was administered intravenously with or without NO inhalation (10 ppm) in each group of five rabbits. Measurements and Main Results: LPS increased the lung leak index, the neutrophils and NO levels in bronchoalveolar lavage fluid, and NO levels produced by resting and stimulated alveolar macrophages. Inhaled NO decreased the lung leak index, the neutrophils and NO levels as measured by nitrite levels in the lavage fluid, and NO produced by the resting and stimulated alveolar macrophages. Inhaled NO also blocked the activities of reactive oxygen species and nuclear factor-κB binding to DNA in lavage cells and in alveolar macrophages. Conclusion: Inhaled NO attenuates LPS-induced acute lung injury, possibly by decreasing NO production in the lungs. The mechanism of reducing NO production resulting from inhaled NO may involve, in part, the activities of reactive oxygen species and/or nuclear factor-κB.
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의과대학 > 의학과 > Journal papers
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