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Hepatitis C virus core protein potentiates TNF-α-induced NF-κB activation through TRAF2-IKKβ-dependent pathway

Title
Hepatitis C virus core protein potentiates TNF-α-induced NF-κB activation through TRAF2-IKKβ-dependent pathway
Authors
Chung Y.M.Park K.J.Choi S.Y.Hwang S.B.Lee S.Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2001
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 284, no. 1, pp. 15 - 19
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Previous work has implicated that the core protein of hepatitis C virus (HCV) may play a modulatory effect on NF-κB activation induced by TNF-α. However, it is unclear how HCV core protein modulates TNF-α-induced NK-κB activation. Here we show that overexpression of HCV core protein potentiates NF-κB activation induced by TNF-α. Expression of dominant negative form of TRAF2 inhibits the synergistic effects of HCV core protein on NF-κB activation, suggesting that HCV core protein potentiates NF-κB activation through TRAF2. Moreover, we demonstrate that HCV core protein potentiates TRAF2-mediated NF-κB activation via IKKβ. In addition, HCV core protein associates with TNF-R1-TRADD-TRAF2 signaling complex, resulting in synergistically activation of NF-κB induced by TNF-α. Thus, these observations indicate that HCV core protein may play an important role in the regulation of the cellular inflammatory and immune responses through NF-κB. © 2001 Academic Press.
DOI
10.1006/bbrc.2001.4936
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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