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Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity

Title
Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity
Authors
Woo S.-H.Kim H.-S.Yun J.-S.Lee M.-K.Oh K.-W.Seong Y.-H.Oh S.-K.Jang C.-G.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2001
Journal Title
Pharmacological Research
ISSN
1043-6618JCR Link
Citation
vol. 43, no. 4, pp. 335 - 340
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The effects of baclofen on the development of reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine were examined in mice. A single administration of morphine induced hyperactivity and the morphine-induced hyperactivity was inhibited dose dependently by the administration of a GABA B receptor agonist, baclofen (1.25, 2.5 and 5 mg kg -1, i.p.). Daily repeated administration of morphine developed reverse tolerance to the hyperactivity of morphine. The concomitant administration of baclofen inhibited the morphine-induced hyperactivity and the baclofen administration prior to and during the chronic administration of morphine in mice inhibited the development of reverse tolerance to the hyperactivity of morphine (10 mg kg -1, s.c.). Postsynaptic dopamine receptor supersensitivity was also developed in reverse-tolerant mice that had received the same morphine. The development of postsynaptic dopamine receptor supersensitivity was evidenced by the enhanced ambulatory activity of apomorphine (2 mg kg -1, s.c.). Baclofen also inhibited the development of postsynaptic dopamine receptor supersensitivity induced by the chronic administration of morphine. These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine may be modulated via the activation of GABA B receptors induced by baclofen. © 2001 Academic Press.
DOI
10.1006/phrs.2000.0789
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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