Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T11:08:38Z | - |
dc.date.available | 2016-08-28T11:08:38Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.other | OAK-643 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218763 | - |
dc.description.abstract | Background: In order to achieve optimal effects, growth factors including platelet-derived growth factor (PDGF) should be delivered with a biodegradable carrier that will release therapeutic concentrations over a sufficient length of time. The purpose of this study was to evaluate the bone regenerative effect of PDGF-BB delivered with a chitosan/tricalcium phosphate (TCP) sponge carrier in a rat calvarial defect model. Methods: The PDGF-BB-loaded chitosan/TCP sponge carrier was fabricated by freeze-drying a mixture of chitosan solution and TCP powder and soaking in a PDGF-BB solution. The release kinetics of PDGF-BB loaded onto the sponge were measured in vitro with 125I-labeled PDGF-BB. Chitosan/TCP sponges with and without PDGF-BB were implanted into 8 mm calvarial defects in rats. Rats were sacrificed at 2 and 4 weeks following implantation, and histologic and histomorphometrical examinations were performed. Results: In vitro evaluation demonstrated that an effective therapeutic concentration of PDGF-BB following a high initial burst release was maintained throughout the examination period. In the histologic examination, the chitosan/TCP sponge carrier promoted osseous healing of the rat calvarial defects as compared to controls. The addition of PDGF-BB to the carrier further enhanced bone regeneration. Evidence of the degraded sponge matrix was observed mingled within the newly formed bone without connective tissue encapsulation. Conclusions: The results of this study support the use of chitosan/TCP sponges as a delivery system for growth factors and demonstrate that PDGF-BB loaded onto chitosan/TCP sponge carriers has an osteogenic effect on bone regeneration in vivo. | - |
dc.language | English | - |
dc.title | The Bone Regenerative Effect of Platelet-Derived Growth Factor-BB Delivered with a Chitosan/Tricalcium Phosphate Sponge Carrier | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 71 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 418 | - |
dc.relation.lastpage | 424 | - |
dc.relation.journaltitle | Journal of Periodontology | - |
dc.identifier.wosid | WOS:000167489100011 | - |
dc.identifier.scopusid | 2-s2.0-0034150308 | - |
dc.author.google | Lee Y.-M. | - |
dc.author.google | Park Y.-J. | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Ku Y. | - |
dc.author.google | Han S.-B. | - |
dc.author.google | Klokkevold P.R. | - |
dc.author.google | Chung C.-P. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |