Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜영 | * |
dc.contributor.author | 서주영 | * |
dc.contributor.author | 김경효 | * |
dc.contributor.author | 김승철 | * |
dc.contributor.author | 정화순 | * |
dc.contributor.author | 유경하 | * |
dc.date.accessioned | 2016-08-28T11:08:37Z | - |
dc.date.available | 2016-08-28T11:08:37Z | - |
dc.date.issued | 2001 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.other | OAK-623 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218754 | - |
dc.description.abstract | Very late antigen-4 (VLA-4), which binds to the extracellular matrix protein fibronectin, is an integrin molecule known to be modulated during mobilization of CD34+ cells, and to be involved in signaling the mobilization stimuli. On the hypothesis that cell cycling status might be different depending on the level of VLA-4 expression, we investigated the DNA contents of human cord blood CD34+ cells during ex vivo expansion by recombinant human thrombopoietin and flt3-ligand with simultaneous measurement of surface VLA-4 at the 1st and 4th week. During this ex vivo expansion, expression of VLA-4 increased and almost all cells became VLA-4+ until the 4th day of culture. Expression of VLA-4 was maintained in the major population of the cultured cells until the 4th week. The cells in S/G2/M phase were greater in number in VLA-4 high fraction than in VLA-4 low fraction (n=4, p<.001). Furthermore, the fraction of cells in S/G2/M phase increased as the expression of VLA-4 became higher. These results suggest that cord blood CD34+ cells expressing high levels of VLA-4 have more proliferative activities. Copyright © The Korean Academy of Medical Sciences. | * |
dc.language | English | * |
dc.title | Cell cycling status of human cord blood CD34+ cells during ex vivo expansion is related to the level of very late antigen expression | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 20 | * |
dc.relation.lastpage | 24 | * |
dc.relation.journaltitle | Journal of Korean Medical Science | * |
dc.identifier.wosid | WOS:000167216800005 | * |
dc.identifier.scopusid | 2-s2.0-0035260931 | * |
dc.author.google | Seoh J.-Y. | * |
dc.author.google | Park H.-Y. | * |
dc.author.google | Chung W.-S. | * |
dc.author.google | Kim S.-C. | * |
dc.author.google | Hahn M.-J. | * |
dc.author.google | Kim K.-H. | * |
dc.author.google | Shin H.-Y. | * |
dc.author.google | Ahn H.-S. | * |
dc.author.google | Park K.-W. | * |
dc.author.google | Ryu K.-H. | * |
dc.contributor.scopusid | 박혜영(7601567979) | * |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | * |
dc.contributor.scopusid | 김경효(35448653000) | * |
dc.contributor.scopusid | 김승철(35264000100) | * |
dc.contributor.scopusid | 정화순(7401983201;54885771500) | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.date.modifydate | 20240301081003 | * |