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dc.contributor.author박혜영-
dc.contributor.author서주영-
dc.contributor.author김경효-
dc.contributor.author김승철-
dc.contributor.author정화순-
dc.contributor.author유경하-
dc.date.accessioned2017-08-28T10:05:02Z-
dc.date.available2017-08-28T10:05:02Z-
dc.date.issued2001-
dc.identifier.issn1011-8934-
dc.identifier.otherOAK-623-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/218754-
dc.description.abstractVery late antigen-4 (VLA-4), which binds to the extracellular matrix protein fibronectin, is an integrin molecule known to be modulated during mobilization of CD34+ cells, and to be involved in signaling the mobilization stimuli. On the hypothesis that cell cycling status might be different depending on the level of VLA-4 expression, we investigated the DNA contents of human cord blood CD34+ cells during ex vivo expansion by recombinant human thrombopoietin and flt3-ligand with simultaneous measurement of surface VLA-4 at the 1st and 4th week. During this ex vivo expansion, expression of VLA-4 increased and almost all cells became VLA-4+ until the 4th day of culture. Expression of VLA-4 was maintained in the major population of the cultured cells until the 4th week. The cells in S/G2/M phase were greater in number in VLA-4 high fraction than in VLA-4 low fraction (n=4, p<.001). Furthermore, the fraction of cells in S/G2/M phase increased as the expression of VLA-4 became higher. These results suggest that cord blood CD34+ cells expressing high levels of VLA-4 have more proliferative activities. Copyright © The Korean Academy of Medical Sciences.-
dc.languageEnglish-
dc.titleCell cycling status of human cord blood CD34+ cells during ex vivo expansion is related to the level of very late antigen expression-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume16-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage20-
dc.relation.lastpage24-
dc.relation.journaltitleJournal of Korean Medical Science-
dc.identifier.wosidWOS:000167216800005-
dc.identifier.scopusid2-s2.0-0035260931-
dc.author.googleSeoh J.-Y.-
dc.author.googlePark H.-Y.-
dc.author.googleChung W.-S.-
dc.author.googleKim S.-C.-
dc.author.googleHahn M.-J.-
dc.author.googleKim K.-H.-
dc.author.googleShin H.-Y.-
dc.author.googleAhn H.-S.-
dc.author.googlePark K.-W.-
dc.author.googleRyu K.-H.-
dc.contributor.scopusid박혜영(7601567979)-
dc.contributor.scopusid서주영(6603709174)-
dc.contributor.scopusid김경효(35448653000)-
dc.contributor.scopusid김승철(35264000100)-
dc.contributor.scopusid정화순(7401983201)-
dc.contributor.scopusid유경하(14038236200)-
dc.date.modifydate20181002081005-


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