View : 38 Download: 0

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometrium in women with endometriosis: A rationale for endometriotic invasiveness

Title
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometrium in women with endometriosis: A rationale for endometriotic invasiveness
Authors
Chung H.-W.Wen Y.Chun S.-H.Nezhat C.Woo B.-H.Lake Polan M.
Ewha Authors
우복희전선희정혜원
SCOPUS Author ID
우복희scopusscopus; 전선희scopus; 정혜원scopus
Issue Date
2001
Journal Title
Fertility and Sterility
ISSN
0015-0282JCR Link
Citation
vol. 75, no. 1, pp. 152 - 159
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: To investigate mRNA expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in ectopic endometriosis tissue and uterine endometrium from women with and without endometriosis throughout the menstrual cycle. Design: Molecular studies in human tissue. Setting: Department of Gynecology and Obstetrics, Reproductive Immunology Laboratory, Stanford University Medical Center. Patient(s): Fifty-three premenopausal woman (23 women with endometriosis and 30 women without endometriosis undergoing laparoscopic surgery). Endometrium and ectopic endometriosis tissue were obtained at the time of surgery.Intervention(s): None. Main Outcome Measure(s): mRNA expression from eutopic and ectopic endometrium was analyzed by quantitative, competitive PCR. Result(s): Both uterine endometrium and ectopic endometriotic tissue from women with endometriosis expressed significantly (P<.05) lower levels of TIMP-3 than endometrium from normal women. Also, ectopic endometrium expressed higher levels of MMP-9 and a higher ratio of MMP-9/TIMP-3 than eutopic endometrium from normal and endometriosis patients. Conclusion(s): These results suggest that ectopic and eutopic endometrium from endometriosis patients may be more invasive and prone to peritoneal implantation because of greater MMP and less TIMP-3 mRNA expression than endometrium from women without endometriosis. Thus, increased proteolytic activity may be one of the reasons for the invasive properties of the endometrium, resulting in the development of endometriosis. Copyright © 2001 American Society for Reproductive Medicine.
DOI
10.1016/S0015-0282(00)01670-8
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE