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Hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated rats

Title
Hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated rats
Authors
Lim H.-K.Kim H.-S.Choi H.-S.Oh S.Choi J.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2000
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741JCR Link
Citation
vol. 72, no. 3, pp. 469 - 474
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, were evaluated against carbon tetrachloride (CCl4)- induced liver damage in rats. Bergenin at a dose of 50, 100 or 200 mg/kg was administered orally once daily for successive 7 days and then a mixture of 0.5 ml/kg (ip) of CCl4 in olive oil (1:1) was injected two times each at 12 and 36 h after the final administration of bergenin. The substantially elevated serum enzymatic activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and γ-glutamyltransferase due to CCl4 treatment were dose dependently restored towards normalization. Meanwhile, the decreased activities of glutathione S-transferase and glutathione reductase were restored towards normalization. In addition, bergenin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of reduced glutathione content in the liver of CCl4-intoxicated rats in a dose dependent fashion. The results of this study clearly indicate that bergenin has a potent hepatoprotective action against CCl4-induced hepatic damage in rats. (C) 2000 Elsevier Science Ireland Ltd.
DOI
10.1016/S0378-8741(00)00260-9
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의학전문대학원 > 의학과 > Journal papers
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