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Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein

Title
Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein
Authors
Oh S.Hahn H.Torrey T.A.Shin H.Choi W.Lee Y.M.Morse III H.C.Kim W.
Ewha Authors
최원자
SCOPUS Author ID
최원자scopus
Issue Date
2000
Journal Title
Biochimica et Biophysica Acta - Gene Structure and Expression
ISSN
0167-4781JCR Link
Citation
vol. 1493, no. 1-2, pp. 219 - 224
Indexed
SCOPUS WOS scopus
Abstract
A combination of RT-PCR with cDNA library screening led to the identification of the human homologue of murine KIF4 (mKIF4), a microtubule- based motor protein. The nucleotide sequence of human KIF4 (hKIF4) comprised part of the 5 untranslated region (UTR), a long open reading frame (ORF) encoding 1232 amino acids, and the entire 3' UTR. Homologies with mKIF4 were 82% and 85% for nucleotides and amino acids, respectively. A single transcript of 5.0 kb was highly expressed in hematopoietic tissues including fetal liver, spleen, and thymus, and adult thymus and bone marrow. Comparison of the ORF with that of mKIF4 revealed some dissimilarities in the putative cargo binding domain which might affect binding specificities. (C) 2000 Published by Elsevier Science B.V.
DOI
10.1016/S0167-4781(00)00151-2
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자연과학대학 > 생명과학전공 > Journal papers
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