Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T11:08:26Z | - |
dc.date.available | 2016-08-28T11:08:26Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.other | OAK-444 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218644 | - |
dc.description.abstract | Platelet-derived growth factor-BB (PDGF-BB) releasing porous chondroitin-4-sulfate (CS)-chitosan sponge was designed with an aim of controlling growth factor delivery in order to improve bone formation. Porous CS-chitosan sponge was fabricated by freeze drying and crosslinking aqueous CS-chitosan solution. PDGF-BB was incorporated into the CS-chitosan sponge by soaking CS-chitosan sponge into the PDGF-BB solution. CS-chitosan sponge retained a porous structure with a 150-200-μm pore diameter that was suitable for cellular migration and osteoid ingrowth. Release rate of PDGF-BB could be controlled by varying the composition of CS in the sponge or initial loading content of PDGF-BB. CS-chitosan sponge induced increased osteoblast migration and proliferation as compared with chitosan sponge alone. Furthermore, the release of PDGF-BB from CS-chitosan sponge significantly enhanced osteoblast proliferation. These results suggest that PDGF-BB-releasing CS-chitosan sponge may be beneficial to enhance bone cell adaptation and regenerative potential when applied in wound sites. Copyright (C) 2000 Elsevier Science B.V. | - |
dc.language | English | - |
dc.title | Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration | - |
dc.type | Article | - |
dc.relation.issue | 2-3 | - |
dc.relation.volume | 67 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 385 | - |
dc.relation.lastpage | 394 | - |
dc.relation.journaltitle | Journal of Controlled Release | - |
dc.identifier.doi | 10.1016/S0168-3659(00)00232-7 | - |
dc.identifier.wosid | WOS:000087631100023 | - |
dc.identifier.scopusid | 2-s2.0-0034601269 | - |
dc.author.google | Park Y.J. | - |
dc.author.google | Lee Y.M. | - |
dc.author.google | Lee J.Y. | - |
dc.author.google | Seol Y.J. | - |
dc.author.google | Chung C.P. | - |
dc.author.google | Lee S.J. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |