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Concentration of vascular endothelial growth factor (VEGF) and transforming growth factor β-1 (TGF-β1) in the serum of patients with cervical cancer: Prediction of response

Title
Concentration of vascular endothelial growth factor (VEGF) and transforming growth factor β-1 (TGF-β1) in the serum of patients with cervical cancer: Prediction of response
Authors
Moon H.-S.Kim S.C.Ahn J.J.Woo B.H.
Ewha Authors
안정자우복희김승철문혜성
SCOPUS Author ID
안정자scopus; 우복희scopusscopus; 김승철scopus; 문혜성scopus
Issue Date
2000
Journal Title
International Journal of Gynecological Cancer
ISSN
1048-891XJCR Link
Citation
vol. 10, no. 2, pp. 151 - 156
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to determine the value of the measurement of serum VEGF and TGF-β1 levels in the diagnosis of cervical cancer and to see whether these levels decrease after treatment for cervical cancer. We measured serum VEGF and TGF-β1 levels through EIA in patients with CIN (n = 35), and cervical squamous cell cancer (n = 48). We also measured serum VEGF, TGF-β1, and SCC antigen levels before and after radiotherapy in 13 cervical squamous cell cancer patients. The sizes of the tumors in those patients were measured by a computer tomography scan or magnetic resonance imaging. The serum VEGF levels were different between CIN and cervical cancer groups (p < 0.1), and the serum TGF-β 1 levels in the cervical cancer group were lower than those in the other groups (P < 0.05). The serum VEGF levels were significantly related to the serum TGF-β 1 levels in the cervical cancer patients (P < 0.01). In the cervical cancer patients, the decrease in the circulating VEGF levels after receiving radiotherapy was related to the decrease in tumor size (P < 0.01). While the measurement of serum VEGF level is adjuvant in diagnosing cervical cancers, serial serum VEGF level measurements may find a clinical use in the follow-up of women treated for cervical cancer.
DOI
10.1046/j.1525-1438.2000.00013.x
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의학전문대학원 > 의학과 > Journal papers
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