Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 하은희 | * |
dc.date.accessioned | 2016-08-28T11:08:25Z | - |
dc.date.available | 2016-08-28T11:08:25Z | - |
dc.date.issued | 2000 | * |
dc.identifier.issn | 1351-0711 | * |
dc.identifier.other | OAK-433 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218636 | - |
dc.description.abstract | Objectives - Oxidative DNA damage has been implicated in carcinogenesis. The DNA damage can be assessed from the urinary excretion of the DNA-repair product 8-hydroxydeoxyguanosine (8-OH-dG). The factors were investigated that influenced the excretion of urinary 8-OH-dG in 78 firefighters. Methods - 53 Out of 78 firefighters were exposed to fire within 5 days of the study and 25 were not. 8-OH-dG was measured by ELISA and the distribution of the genotypes of CYP1A1, CYP2E1, GSTM1, and GSTT1 was measured by polymerase chain reaction. Results - The homozygous wild type frequencies of CYP1A1 MspI, CYP1A1 ileval, CYP2E1, GSTM1, and GSTT1 were 31.5%, 56.2%, 60.3%, 50.7%, and 53.4%, respectively. The geometric mean of urinary 8-OH-dG was 14.1 ng/mg creatinine in more active firefighters and 12.3 ng/mg creatinine in non-exposed and less active subjects. Significantly increased concentrations of urinary 8-OH-dG were found to be associated with cigarette smoking, and 14% of the variation of 8-OH-dG was explained by cigarettes smoked per day. The CYP1A1 MspI, CYP1A1 ile-val, GSTM1, and GSTT1 genetic polymorphisms were not found to be significantly associated with the urinary excretion of 8-OH-dG. However, the subjects carrying the CYP2E1 mutant type excreted higher concentrations of 8-OH-dG and there was a marginally significant interaction of GSTT1 with firefighting activity. Multiple regression analysis confirmed that smoking was the strongest predictor of excretion of 8-OH-dG. Age, body mass index, and firefighting activity were not significant predictive factors for urinary 8-OH-dG. Conclusion - Smoking and CYP2E1 gene polymorphism may be important factors in carcinogenesis and the GSTT1 positive genotype may be a genetic susceptibility factor in firefighters who are exposed regularly to various chemical carcinogens. | * |
dc.language | English | * |
dc.title | Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 370 | * |
dc.relation.lastpage | 375 | * |
dc.relation.journaltitle | Occupational and Environmental Medicine | * |
dc.identifier.doi | 10.1136/oem.57.6.370 | * |
dc.identifier.wosid | WOS:000087150500002 | * |
dc.identifier.scopusid | 2-s2.0-0034024265 | * |
dc.author.google | Hong Y.-C. | * |
dc.author.google | Park H.-S. | * |
dc.author.google | Ha E.-H. | * |
dc.contributor.scopusid | 하은희(7003615774) | * |
dc.date.modifydate | 20240415125553 | * |