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Requirement of MEF2D in the induced differentiation of HL60 promyeloid cells

Title
Requirement of MEF2D in the induced differentiation of HL60 promyeloid cells
Authors
Shin H.-M.Seoh J.-Y.Chung H.-Y.Choi S.-J.Hahn M.-J.Kang J.-S.Choi M.-S.Han T.-H.
Ewha Authors
서주영
SCOPUS Author ID
서주영scopus
Issue Date
1999
Journal Title
Molecular Immunology
ISSN
0161-5890JCR Link
Citation
vol. 36, no. 18, pp. 1209 - 1214
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The regulatory role of MEF2 (myocyte enhancer binding factor 2) proteins in nonmuscle tissues has not been well characterized. We examined the expression of MEF2 family members, namely, MEF2A, -B, -C, and -D, in the differentiation of HL60 promyeloid cells and observed the remarkable increase in the expressions of MEF2A and MEF2D proteins during the differentiation process into monocytes. To examine the role of MEF2, we expressed a dominant- negative form of MEF2D, without its transactivation domain, in HL60 cells. When the HL60 cell line expressing the mutant MEF2D was induced to differentiate by VitD3 treatment, cell surface expression of CD14 and the ability to reduce NBT, which are important characteristics of differentiated monocytes, were significantly decreased compared with control HL60 cells. These results show that MEF2D is required in the differentiation process along the monocyte/macrophage lineage, (C) 2000 Elsevier Science Ltd.
DOI
10.1016/S0161-5890(99)00140-6
Appears in Collections:
의과대학 > 의학과 > Journal papers
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