Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T11:08:21Z | - |
dc.date.available | 2016-08-28T11:08:21Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | OAK-341 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218589 | - |
dc.description.abstract | In order to discover new cancer chemopreventive agents from natural or synthetic products, a structurally diverse class of chemopreventive agents was evaluated using in vitro biomarker of inhibition of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cultured mouse epidermal 308 (ME 308) cells. As a result, apigenin, benzylisothiocyanate, curcumin, diallyl disulfide, N-(4-hydroxyphenyl)retinamide (4-HPR), menadione, miconazole, nordihydroguaiaretic acid (NDGA) and phenethyl isothiocyanate showed potent inhibitory effects in this process. A chemically diverse group of compounds was included in the evaluation, such as flavonoids, retinoids, isothiocyanates, sulfur-containing compounds and phenolic antioxidant compounds. These data are suggestive to understand the cancer chemopreventive potential mediated by these substances. | - |
dc.language | English | - |
dc.title | Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity | - |
dc.type | Review | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 22 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 559 | - |
dc.relation.lastpage | 564 | - |
dc.relation.journaltitle | Archives of Pharmacal Research | - |
dc.identifier.wosid | WOS:000084372700005 | - |
dc.identifier.scopusid | 2-s2.0-0033255389 | - |
dc.author.google | Lee S.K. | - |
dc.author.google | Pezzuto J.M. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |