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Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat

Title
Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat
Authors
Kim Y.I.Kim S.H.Kim D.Y.Lee H.W.Shin H.-C.Chung J.-M.Han H.C.Na H.S.Hong S.K.
Ewha Authors
정준모
SCOPUS Author ID
정준모scopus
Issue Date
1999
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
vol. 274, no. 2, pp. 99 - 102
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The retinohypothalamic tract (RHT) is a neural pathway through which photic time cues are delivered directly to the mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN). Although the excitatory amino acid glutamate is the primary neurotransmitter in the RHT, other substances such as substance P (SP) also have been suggested to play a role. The present study tested the hypothesis that SP participates in retinohypothalamic transmission and selectively modulates either N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated neurotransmission. The SP antagonist L-703,606 depressed the excitatory postsynaptic current (EPSC) evoked by optic nerve stimulation in SCN neurons in rat hypothalamic slices. The SP antagonist also had a similar depressive effect on the NMDA and non-NMDA receptor-mediated components of the EPSC. These results suggest that SP is an excitatory neuromodulator contributing to the expression of both the NMDA and non-NMDA receptor-mediated components of retinohypothalamic transmission. Copyright (C) 1999 Elsevier Science Ireland Ltd.
DOI
10.1016/S0304-3940(99)00681-3
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자연과학대학 > 생명과학전공 > Journal papers
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