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Evaluation of antibody responses to pneumococcal vaccines with ELISA and opsonophagocytic assay

Title
Evaluation of antibody responses to pneumococcal vaccines with ELISA and opsonophagocytic assay
Authors
Kim K.H.Seoh J.-Y.
Ewha Authors
서주영김경효
SCOPUS Author ID
서주영scopus; 김경효scopus
Issue Date
1999
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 14, no. 5, pp. 475 - 479
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Antibodies to a capsular polysaccharide (PS) provide protection against Streptococcus pneumoniae which express the homologous capsular serotype, and pneumococcal vaccines are designed to induce antibodies in the capsular PS. Levels and opsonophagocytic capacity of antibodies to the capsular PS of S. pneumoniae serotype 19F were determined by sera from adults immunized with 23-valent S. pneumoniae capsular PS vaccines. Geometric means of IgG anti-19F antibody level and specific opsonic titer rise significantly after immunization. The level of anticapsular PS antibodies for S. pneumoniae 19F serotype is fairly well correlated (r2=0.63) with the opsonophagocytic activities of sera. However, 3.7% (1/27) of serum samples display strikingly less opsonophagocytic activity than expected on the basis of their antibody level. Thus, antibody level may be of general use in predicting vaccine-induced protection among adults for 19F serotype. However, the opsonic activity data suggest that antibody levels are not always indicative of functional antibody. Copyright ©The Korean Academy of Medical Sciences.
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의학전문대학원 > 의학과 > Journal papers
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