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Effect of Na-hyaluronan on stromal and endothelial healing in experimental corneal alkali wounds

Title
Effect of Na-hyaluronan on stromal and endothelial healing in experimental corneal alkali wounds
Authors
Chung J.-H.Park Y.-K.Paek S.-M.Chong Y.-H.Kim W.-K.
Ewha Authors
정영해
SCOPUS Author ID
정영해scopus
Issue Date
1999
Journal Title
Ophthalmic Research
ISSN
0030-3747JCR Link
Citation
vol. 31, no. 6, pp. 432 - 439
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The healing of stroma and endothelium after a standardized corneal alkali wound was evaluated in sodium-hyaluronan (Na-HA)-treated eyes. Alkali wounds were produced in one eye of each rabbit by applying a 5.5-mm round filter paper soaked in 1 N NaOH onto the central cornea for 60 s. Eyes were then treated with either 1% Na-HA (the treatment group) or phosphate-buffered saline (the control group) 4 times per day for 3 weeks. Endothelial wound morphometry was performed after alizarin red and trypan blue staining, while stromal healing was assessed by counting polymorphonuclear leukocytes (PMNs) and keratocytes in the central and marginal wound areas. During the early healing period the stroma treated with Na-HA had less PMNs than that of the control group. The size of the endothelial defect area measured 5 days after injury was significantly smaller in the Na-HA group than in the control corneas. The present findings indicate that topically applied 1% Na-HA affects stromal and endothelial healing during the early repair process after corneal alkali wounds.
DOI
10.1159/000055568
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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