Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서주영 | - |
dc.date.accessioned | 2016-08-28T11:08:18Z | - |
dc.date.available | 2016-08-28T11:08:18Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0166-3542 | - |
dc.identifier.other | OAK-294 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218560 | - |
dc.description.abstract | The compound purified from the fruit of Melia azedarach exerted an antiviral effect on herpes simplex virus-1 (HSV-1) in Vero cells. It was identified as 28-deacetylsendanin (28-DAS). The 50% inhibitory concentration (IC50) of 28-DAS was 1.46 μg/ml without cytotoxicity at 400 μg/ml on Vero cells. Electron microscopy showed that low electron-dense cores of newly synthesized nucleocapsids remained in swollen nuclei and no extracellular virus particles were observed at 15 h p.i. Consistent with this result, it was confirmed by a plaque assay that few infectious progeny viruses were released from the 28-DAS-treated virus-infected cells at 24 h p.i. Intracellular viruses in 28-DAS-treated virus-infected cells were 23% of untreated and infected cells. The synthesis of thymidine kinase (TK) was reduced by 28-DAS at early stage. In conclusion, 28-DAS inhibited the replication of HSV-1, reduced the synthesis of HSV-1 TK, and led to the formation of defective nucleocapsids. Copyright (C) 1999 Elsevier Science B.V. | - |
dc.language | English | - |
dc.title | Antiviral effects of 28-deacetylsendanin on herpes simplex virus-1 replication | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 43 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 103 | - |
dc.relation.lastpage | 112 | - |
dc.relation.journaltitle | Antiviral Research | - |
dc.identifier.doi | 10.1016/S0166-3542(99)00037-6 | - |
dc.identifier.wosid | WOS:000082780100004 | - |
dc.identifier.scopusid | 2-s2.0-0032849792 | - |
dc.author.google | Kim M. | - |
dc.author.google | Kim S.K. | - |
dc.author.google | Park B.N. | - |
dc.author.google | Lee K.H. | - |
dc.author.google | Min G.H. | - |
dc.author.google | Seoh J.Y. | - |
dc.author.google | Park C.G. | - |
dc.author.google | Hwang E.S. | - |
dc.author.google | Cha C.Y. | - |
dc.author.google | Kook Y.H. | - |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | - |
dc.date.modifydate | 20230210140937 | - |