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The effects of peripheral leukocytes on the hippocampal neuronal changes in transient global ischemia and unilateral cerebral hemispheric infarction

Title
The effects of peripheral leukocytes on the hippocampal neuronal changes in transient global ischemia and unilateral cerebral hemispheric infarction
Authors
Lee H.W.Koo H.Choi K.G.Park K.D.Lee B.C.
Ewha Authors
최경규구혜수박기덕이향운
SCOPUS Author ID
최경규scopus; 구혜수scopus; 박기덕scopus; 이향운scopus
Issue Date
1999
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 14, no. 3, pp. 304 - 314
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The participation of activated leukocytes and subsequent production of chemical mediators has been well accepted in the pathophysiology of hypoxic-ischemic injury. This study was performed to see the effects of leukocytes on hippocampal neuronal damage in transient global ischemia induced by 10-min occlusion of bilateral common carotid arteries (CCAs) with reperfusion for various times, and in complete unilateral ischemia induced by 24-hr ligation of left CCA. Leukopenia was induced by intraperitoneal injection of cyclophosphamide for 4 days. The results showed that hippocampal neuronal damages were worse at 6-hr reperfusion in leukopenic experimental group than in the control group. In comparison, 24-hr and 3-day reperfusion leukopenic groups showed less numbers of damaged neurons and milder changes. The 5-day reperfusion group showed inconsistent changes. Unilateral CCA occlusion showed extensive infarction in 83.3% of gerbils in the control group, compared to 25% of gerbils in the experimental group (p<0.05). These results strongly suggest that the number of peripheral leukocytes were closely related to the development of delayed neuronal damage of hippocampus in transient global ischemia and the incidence of infarction induced by 24-hr unilateral CCA ligation. Copyright © The Korean Academy of Medical Sciences.
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의과대학 > 의학과 > Journal papers
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