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Synthesis and hybridization property of sugar and phosphate linkage modified oligonucleotides

Title
Synthesis and hybridization property of sugar and phosphate linkage modified oligonucleotides
Authors
Jeong L.S.Lee J.H.Jung K.-E.Moon H.R.Kim K.Lim H.
Ewha Authors
정낙신
Issue Date
1999
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 7, no. 7, pp. 1467 - 1473
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
1-[3-Deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-3-C-hydroxymethyl-2-O-(2-methoxyethoxymethyl)-β-D-erythro-pentofuranosyl]thymine (13) was synthesized from 1,2-isopropylidene-D-xylose (1) as a building block of modified oligonucleotides. Three types of novel oligonucleotides were synthesized from 13 and their T(m)s were compared with those of the corresponding natural oligonucleotides. It was found that our synthesized oligomers had lower affinity to DNA and RNA than the natural oligomers. Copyright (C) 1999 Elsevier Science Ltd.
DOI
10.1016/S0968-0896(99)00061-9
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약학대학 > 약학과 > Journal papers
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