Synthesis of L-sangivamycin and toyocamycin analogues and their inhibitory activities of Ser/Thr protein kinases

Abstract

Novel L-sangivamycin and toyocamycin analogues were synthesized and evaluated for Cdc2 protein kinase activity. Among the compounds tested, L- xylose derivative and L-arabinose derivative exhibited potent inhibitory activity against Cdc2 protein kinase with IC50 values of 3.7 and 1.6 μM, respectively.