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Synthesis of L-sangivamycin and toyocamycin analogues and their inhibitory activities of Ser/Thr protein kinases

Title
Synthesis of L-sangivamycin and toyocamycin analogues and their inhibitory activities of Ser/Thr protein kinases
Authors
Chun M.W.Shin D.H.Song S.Y.Lee Y.H.Lee C.H.Jeong L.S.Lee S.K.
Ewha Authors
정낙신
Issue Date
1999
Journal Title
Nucleosides and Nucleotides
ISSN
0732-8311JCR Link
Citation
vol. 18, no. 4-5, pp. 617 - 618
Indexed
SCOPUS WOS scopus
Abstract
Novel L-sangivamycin and toyocamycin analogues were synthesized and evaluated for Cdc2 protein kinase activity. Among the compounds tested, L- xylose derivative and L-arabinose derivative exhibited potent inhibitory activity against Cdc2 protein kinase with IC50 values of 3.7 and 1.6 μM, respectively.
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약학대학 > 약학과 > Journal papers
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