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Diffuse micronodular lung disease: HRCT and pathologic findings

Title
Diffuse micronodular lung disease: HRCT and pathologic findings
Authors
Lee K.S.Kim T.S.Han J.Hwang J.H.Yoon J.H.Kim Y.Yoo S.Y.
Ewha Authors
김유경
SCOPUS Author ID
김유경scopus
Issue Date
1999
Journal Title
Journal of Computer Assisted Tomography
ISSN
0363-8715JCR Link
Citation
vol. 23, no. 1, pp. 99 - 106
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: The purpose of our study was to compare the findings seen on HRCT with those from pathologic examination in patients with diffuse micronodular lung disease (DMLD). Method: Forty consecutive patients with biopsy-proven DMLD (each nodule being <5 mm in diameter and occupying more than two-thirds of lung volume on chest radiograph) were included. High resolution CT (HRCT) scans were analyzed with particular attention to the location of nodules in and around the secondary pulmonary lobule (centrilobular, perilymphatic, and random) and the zonal distribution. The findings were compared to pathology. Results: CT scans showed centrilobular nodules in the patients with diffuse panbronchiolitis (n = 4), infectious bronchiolitis [n = 4; Hemophilus influenzae (n = 3) and Mycoplasma pneumoniae (n = 1)], hypersensitivity pneumonia (n = 3), bronchogenic disseminated tuberculosis (n = 3), pneumoconiosis (n = 1), primary lymphoma of the lung (n = 1), and foreign body-induced necrotizing vasculitis (n = 1). They demonstrated perilymphatic nodules in the patients with pneumoconiosis (n = 5), sarcoidosis (n = 2), and amyloidosis (n = 2). They demonstrated micronodules of random distribution in the patients with miliary tuberculosis (n = 9) and pulmonary metastasis (n = 5). Upper and middle zonal predominance was seen in two of two patients with sarcoidosis and in two of six patients with pneumoconiosis. The CT location of nodules in the secondary pulmonary lobule represented the location and nature of the lesion on pathologic examination. Conclusion: By showing the distribution of micronodules in and around the secondary pulmonary lobule, HRCT enables the narrowing of the differential diagnosis of DMLD. CT findings reflect gross morphologic features of pathologic examination.
DOI
10.1097/00004728-199901000-00022
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의학전문대학원 > 의학과 > Journal papers
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