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Action of dopamine as inhibitory neuromodulator in jellyfish synapse

Title
Action of dopamine as inhibitory neuromodulator in jellyfish synapse
Authors
Chung J.-M.Spencer A.N.
Ewha Authors
정준모
SCOPUS Author ID
정준모scopus
Issue Date
1998
Journal Title
Journal of Biochemistry and Molecular Biology
ISSN
1225-8687JCR Link
Citation
vol. 31, no. 3, pp. 264 - 268
Indexed
SCOPUS WOS scopus
Abstract
Dopamine (DA) acts on swimming motor neurons (SMNs) of Polyorchis penicillatus as an inhibitory neurotransmitter by hyperpolarizing their membrane potentials, which results from the activation of voltage-sensitive potassium channels mediated through a D2-type receptor. In addition, DA, and not the hyperpolarized membrane potential, directly decreased the input resistance of SMNs by ca. 50% from 1.42 to 0.68 GΩ. It strongly indicates that DA can shunt other excitatory synaptic signals onto SMNs where DA usually elicited much greater responses in their neuntes than soma. All these evidences suggest that DA may operate in this primitive nervous system in dual modes as an inhibitory neurotransmitter and neuromodulator as well.
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자연과학대학 > 생명과학전공 > Journal papers
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