View : 20 Download: 0

Effect of topical Na-hyaluronan on hemidesmosome formation in n-heptanol-induced corneal injury

Title
Effect of topical Na-hyaluronan on hemidesmosome formation in n-heptanol-induced corneal injury
Authors
Chung J.-H.Kim W.-K.Lee J.-S.Pae Y.-S.Kim H.-J.
Ewha Authors
배영숙김원기정장현
SCOPUS Author ID
배영숙scopus; 정장현scopus
Issue Date
1998
Journal Title
Ophthalmic Research
ISSN
0030-3747JCR Link
Citation
vol. 30, no. 2, pp. 96 - 100
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The present study investigated the effect of Na-hyaluronan (Na-HA) on the hemidesmosome morphogenesis in n-heptanol-induced corneal wounds. Central epithelial wounds were induced in the rabbit cornea by applying a 5.5-mm round filter paper, which was soaked in n-heptanol, for 60 s. 1% Na-HA in phosphate-buffered saline (PBS) or PBS alone were topically administered to the wounded cornea 4 times daily for up to 7 days. Epithelial healing rates during the first 2 days were not altered by Na-HA. The number of hemidesmosomes in the basement membrane of the central cornea was significantly increased in both 3- and 7-day groups after treatment with 1% Na-HA. The results suggest that topically applied 1% Na-HA may enhance the formation of hemidesmosomes during the early healing phase in n-heptanol-induced corneal wounds.
DOI
10.1159/000055460
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE