Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박은미 | * |
dc.contributor.author | 임은진 | * |
dc.contributor.author | 안영호 | * |
dc.date.accessioned | 2016-08-28T11:08:00Z | - |
dc.date.available | 2016-08-28T11:08:00Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-19046 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218372 | - |
dc.description.abstract | Mer signaling increases the transcriptional activity of liver X receptor (LXR) to promote the resolution of acute sterile inflammation. Here, we aimed to understand the pathway downstream of Mer signaling after growth arrest-specific protein 6 (Gas6) treatment that leads to LXR expression and transcriptional activity in mouse bone-marrow derived macrophages (BMDM). Gas6-induced increases in LXR alpha and LXR beta and expression of their target genes were inhibited in BMDM from STAT1(-/-) mice or by the STAT1-specific inhibitor fludarabine. Gas6-induced STAT1 phosphorylation, LXR activation, and LXR target gene expression were inhibited in BMDM from Mer(-/-) mice or by inhibition of PI3K or Akt. Gas6-induced Akt phosphorylation was inhibited in BMDM from STAT1(-/-) mice or in the presence of fludarabine. Gas6-induced LXR activity was enhanced through an interaction between LXRa and STAT1 on the DNA promoter of Arg2. Additionally, we found that Gas6 inhibited lipopolysaccharide (LPS)-induced nitrite production in a STAT1 and LXR pathway-dependent manner in BMDM. Additionally, Mer-neutralizing antibody reduced LXR and Arg2 expression in lung tissue and enhanced NO production in bronchoalveolar lavage fluid in LPS-induced acute lung injury. Our data suggest the possibility that the Gas6-Mer-PI3K/Akt-STAT1-LXR-Arg2 pathway plays an essential role for resolving inflammatory response in acute lung injury. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages | * |
dc.type | Article | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | SCIENTIFIC REPORTS | * |
dc.identifier.doi | 10.1038/srep29673 | * |
dc.identifier.wosid | WOS:000379579900001 | * |
dc.identifier.scopusid | 2-s2.0-84978388845 | * |
dc.author.google | Kim, Si-Yoon | * |
dc.author.google | Lim, Eun-Jin | * |
dc.author.google | Yoon, Young-So | * |
dc.author.google | Ahn, Young-Ho | * |
dc.author.google | Park, Eun-Mi | * |
dc.author.google | Kim, Hee-Sun | * |
dc.author.google | Kang, Jihee Lee | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박은미(35933416400) | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.date.modifydate | 20240222132209 | * |