View : 23 Download: 0
Modafinil improves monocrotaline-induced pulmonary hypertension rat model
- Modafinil improves monocrotaline-induced pulmonary hypertension rat model
- Lee, Hyeryon; Kim, Kwan Chang; Cho, Min-Sun; Suh, Suk-hyo; Hong, Young Mi
- Ewha Authors
- 홍영미; 서석효; 조민선; 김관창
- SCOPUS Author ID
- 홍영미; 서석효; 조민선; 김관창
- Issue Date
- Journal Title
- PEDIATRIC RESEARCH
- 0031-3998; 1530-0447
- vol. 80, no. 1, pp. 119 - 127
- NATURE PUBLISHING GROUP
- SCI; SCIE; SCOPUS
- BACKGROUND: Pulmonary arterial hypertension (PAH) progressively leads to increases in pulmonary vasoconstriction. Modafinil plays a role in vasorelaxation and blocking KCa3.1 channel with a result of elevating intracellular cyclic adenosine monophosphate (cAMP) levels. The purpose of this study is to evaluate the effects on modafinil in monocrotaline (MCT)-induced PAH rat. METHODS: The rats were separated into three groups: the control group, the monocrotaline (M) group (MCT 60 mg/kg), and the modafinil (MD) group (MCT 60 mg/kg + modafinil). RESULTS: Reduced right ventricular pressure (RVP) was observed in the MD group. Right ventricular hypertrophy was improved in the MD group. Reduced number of intra-acinar pulmonary arteries and medial wall thickness were noted in the MD group. After the administration of modafinil, protein expressions of endothelin-1 (ET-1), endothelin receptor A (ERA) and KCa3.1 channel were significantly reduced. Modafinil suppressed pulmonary artery smooth muscle cell (PASMC) proliferation via cAMP and KCa3.1 channel. Additionally, we confirmed protein expressions such as Bcl-2-associated X, vascular endothelial growth factor, tumor necrosis factor-alpha, and interleukin-6 were reduced in the MD group. CONCLUSION: Modafinil improved PAH by vasorelaxation and a decrease in medial thickening via ET-1, ERA, and KCa3.1 down regulation. This is a meaningful study of a modafinil in PAH model.
- Appears in Collections:
- 의학전문대학원 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.