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Metabolic health is more closely associated with prevalence of cardiovascular diseases or stroke than obesity A cross-sectional study in Korean populations

Title
Metabolic health is more closely associated with prevalence of cardiovascular diseases or stroke than obesity A cross-sectional study in Korean populations
Authors
Byun, A. RiKwon, SeungwonLee, Sang WhaShim, Kyung WonLee, Hong Soo
Ewha Authors
이상화이홍수심경원변아리
SCOPUS Author ID
이상화scopus; 이홍수scopus; 심경원scopus
Issue Date
2016
Journal Title
MEDICINE
ISSN
0025-7974JCR Link1536-5964JCR Link
Citation
vol. 95, no. 24
Keywords
cardiovascular diseasemetabolically healthy obeseobesityrisk factorstroke prevalence
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Mounting evidence suggests that not all obese subjects are at increased cardiovascular risk. However, the relationship between the metabolically healthy obese (MHO) phenotype and cardiovascular diseases (CVDs) or stroke remains unclear. Therefore, we retrospectively investigated the prevalence of CVDs or stroke according to metabolic health with obese. We studied 3695 subjects (40-85 years) from the Fifth Korean National Health and Nutrition Examination Survey. Participants were divided into 2 groups and 6 subgroups based on the body mass index (BMI) and metabolic syndrome (MetS) components: healthy (exhibiting none of the 5 MetS components) with the followings: healthy-normal weight (BMI <23 kg/m(2)), healthy-overweight (BMI=23-24.9 kg/m(2)), and healthy-obese (BMI >= 25kg/m(2)); and unhealthy (exhibiting 2 or more MetS components) with the followings: unhealthy-normal weight, unhealthy-overweight, and unhealthy-obese. In the healthy group (n=1726), there were 76 CVDs or stroke patients (4.4%), whereas in the unhealthy group (n=1969), there were 170 (8.6%). The prevalence was significantly different between the 2 groups (P<0.001). However, the prevalence was not significantly different among healthy subgroups (P=0.4072). The prevalence in unhealthy subgroups also demonstrated no statistically significant difference (P=0.3798). We suggest that the prevalence of CVDs or stroke is different between metabolically healthy and unhealthy phenotype. Furthermore, MHO did not reveal higher CVDs or stroke prevalence rather than metabolically healthy other groups. Additional cohort studies are needed to explain causality between CVDs or stroke incidence and subjects exhibiting the MHO phenotype.
DOI
10.1097/MD.0000000000003902
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의학전문대학원 > 의학과 > Journal papers
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