View : 549 Download: 189
The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease
- Title
- The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease
- Authors
- Lee, Hye Won; Chung, Sook Hee; Moon, Chang Mo; Che, Xiumei; Kim, Seung Won; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, Jae Hee
- Ewha Authors
- 문창모
- SCOPUS Author ID
- 문창모
- Issue Date
- 2016
- Journal Title
- MEDICINE
- ISSN
- 0025-7974
1536-5964
- Citation
- MEDICINE vol. 95, no. 23
- Publisher
- LIPPINCOTT WILLIAMS &
WILKINS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Genetic variants in IL12B, encoding the p40 subunit common in interleukin-12 (IL-12) and interleukin-23, were identified as the susceptibility loci for inflammatory bowel disease (IBD). This study aimed to identify the correlation of serum IL-12B expression with disease activity in patients with IBD and evaluate the possibility of IL12B as a biomarker for assessing inflammatory status in IBD. A total of 102 patients with IBD, including 38, 32, and 32 patients with Crohn's disease (CD), ulcerative colitis (UC), and intestinal Behc, et's disease (intestinal BD), respectively, were included. The clinical and laboratory data from the patients were collected at the time of serum IL-12B measurement. Serum IL-12B levels were measured using an enzyme-linked immunosorbent assay. The median IL-12B levels in patients with CD, UC, and intestinal BD were significantly higher than those in controls (1.87, 2.74, and 2.73 pg/mL, respectively, vs. 1.42 pg/mL, all P < 0.05). IL-12B concentrations were associated with disease activity in patients with UC and intestinal BD but not in those with CD. IL-12B levels were increased with increasing disease activity in patients with UC (P < 0.001). Likewise, patients with active intestinal BD had higher IL-12B levels than those without active disease (P = 0.008). IL-12B levels were correlated with the endoscopic disease activity of UC (P = 0.002) and intestinal BD (P = 0.001) but not that of CD. Serum IL-12B levels were significantly correlated with clinical and endoscopic disease activity in patients with UC and intestinal BD, suggesting its potential use as a biomarker for assessing disease activity in these patients.
- DOI
- 10.1097/MD.0000000000003772
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
-
The Correlation of Serum IL-12B Expression With Disease Activity in Patients With Inflammatory Bowel Disease.pdf(286.76 kB)
Download
- Export
- RIS (EndNote)
- XLS (Excel)
- XML