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Enzymatic Process for High-Yield Turanose Production and Its Potential Property as an Adipogenesis Regulator

Title
Enzymatic Process for High-Yield Turanose Production and Its Potential Property as an Adipogenesis Regulator
Authors
Park, Min-OhLee, Byung-HooLim, EunjinLim, Ji YeKim, YuriPark, Cheon-SeokLee, Hyeon GyuKang, Hee-KwonYoo, Sang-Ho
Ewha Authors
김유리
SCOPUS Author ID
김유리scopus
Issue Date
2016
Journal Title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN
0021-8561JCR Link1520-5118JCR Link
Citation
vol. 64, no. 23, pp. 4758 - 4764
Keywords
turanoseamylosucrasefructoseadipogenesisNeisseria polysaccharea
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Turanose is a sucrose isomer naturally existing in honey and a promising functional sweetener due to its low glycemic response. In this study, the extrinsic fructose effect on turanose productivity was examined in Neisseria amylosucrase reaction. Turanose was produced, by increasing the amount of extrinsic fructose as a reaction modulator, with high concentration of sucrose substrate, which resulted in 73.7% of production yield. In physiological functionality test, lipid accumulation in 3T3-L1 preadipocytes in the presence of high amounts of pure glucose was attenuated by turanose substitution in a dose-dependent manner. Turanose treatments at concentrations representing 50%, 75%, and 100% of total glucose concentration in cell media significantly reduced lipid accumulation by 18%, 35%, and 72%, respectively, as compared to controls. This result suggested that turanose had a positive role in controlling adipogenesis, and enzymatic process of turanose production has a potential to develop a functional food ingredient for controlling obesity and related chronic diseases.
DOI
10.1021/acs.jafc.5b05849
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신산업융합대학 > 식품영양학과 > Journal papers
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