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Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences

Title
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
Authors
Poznik, G. DavidXue, YaliMendez, Fernando L.Willems, Thomas F.Massaia, AndreaSayres, Melissa A. WilsonAyub, QasimMcCarthy, Shane A.Narechania, ApurvaKashin, SevaChen, YuanBanerjee, RubyRodriguez-Flores, Juan L.Cerezo, MariaShao, HaojingGymrek, MelissaMalhotra, AnkitLouzada, SandraDesalle, RobRitchie, Graham R. S.Cerveira, ElizaFitzgerald, Tomas W.Garrison, ErikMarcketta, AnthonyMittelman, DavidRomanovitch, MalloryZhang, ChengshengZheng-Bradley, XiangqunAbecasis, Goncalo R.McCarroll, Steven A.Flicek, PaulUnderhill, Peter A.Coin, LachlanZerbino, Daniel R.Yang, FengtangLee, CharlesClarke, LauraAuton, AdamErlich, YanivHandsaker, Robert E.Bustamante, Carlos D.Tyler-Smith, Chris1000 Genomes Project Consortium
Ewha Authors
Charles Lee
SCOPUS Author ID
Charles Leescopus
Issue Date
2016
Journal Title
NATURE GENETICS
ISSN
1061-4036JCR Link1546-1718JCR Link
Citation
vol. 48, no. 6, pp. 593 - +
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26 worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 variants, including single-nucleotide variants, multiple-nucleotide variants, insertions and deletions, short tandem repeats, and copy number variants. Of these, copy number variants contribute the greatest predicted functional impact. We constructed a calibrated phylogenetic tree on the basis of binary single-nucleotide variants and projected the more complex variants onto it, estimating the number of mutations for each class. Our phylogeny shows bursts of extreme expansion in male numbers that have occurred independently among each of the five continental superpopulations examined, at times of known migrations and technological innovations.
DOI
10.1038/ng.3559
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일반대학원 > 생명과학과 > Journal papers
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