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Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease

Title
Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease
Authors
Ye, Byoung SeokLee, YoonjuKwak, KichangPark, Yeong-HunHam, Jee HyunLee, Jae JungShin, Na-YoungLee, Jong-MinSohn, Young H.Lee, Phil Hyu
Ewha Authors
신나영
SCOPUS Author ID
신나영scopus
Issue Date
2016
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
1387-2877JCR Link1875-8908JCR Link
Citation
vol. 52, no. 4, pp. 1237 - 1243
Keywords
Alzheimer's diseasedementia with Lewy bodiesventricular enlargement
Publisher
IOS PRESS
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 +/- 7.9% versus 62.8 +/- 9.0%, respectively; p = 0.001) or the NC group (61.9 +/- 9.9%, p = 0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.
DOI
10.3233/JAD-160062
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의학전문대학원 > 의학과 > Journal papers
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