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Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013

Title
Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013
Authors
Cho, Eun YoungChoi, Eun HwaKang, Jin HanKim, Kyung-HyoKim, Dong SooKim, Yae-JeanAhn, Young MinEun, Byung WookOh, Sung HeeCha, Sung-HoCho, Hye-KyungHong, Young JinKim, Kwang NamKim, Nam HeeKim, Yun-KyungKim, Jong-HyunLee, HyunjuLee, TaekjinKim, Hwang MinLee, Kun SongKim, Chun SooPark, Su EunKim, Young MiOh, Chi EunMa, Sang HyukJo, Dae SunChoi, Young YounLee, JinaBae, Geun-RyangPark, OkPark, Young-JoonKim, Eun SeongLee, Hoan Jong
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
2016
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link1598-6357JCR Link
Citation
vol. 31, no. 7, pp. 1082 - 1088
Keywords
Streptococcus pneumoniaeSerotypePneumococcal Vaccines
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
This study was performed to measure early changes in the serotype distribution of pneumococci isolated from children with invasive disease during the 3-year period following the introduction of 10- and 13-valent pneumococcal conjugate vaccines (PCVs) in Korea. From January 2011 to December 2013 at 25 hospitals located throughout Korea, pneumococci were isolated among children who had invasive pneumococcal disease (IPD). Serotypes were determined using the Quellung reaction, and the change in serotype distribution was analyzed. Seventy-five cases of IPD were included. Eighty percent of patients were aged 3-59 months, and 32% had a comorbidity that increased the risk of pneumococcal infection. The most common serotypes were 19A (32.0%), 10A (8.0%), and 15C (6.7%). The PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F, and 6A) accounted for 14.7% of the total isolates and the PCV13 minus PCV7 types (1, 3, 5, 7F, and 19A) accounted for 32.0% of the total isolates. Serotype 19A was the only serotype in the PCV13 minus PCV7 group. The proportion of serotype 19A showed decreasing tendency from 37.5% in 2011 to 22.2% in 2013 (P = 0.309), while the proportion of non-PCV13 types showed increasing tendency from 45.8% in 2011 to 72.2% in 2013 (P = 0.108). Shortly after the introduction of extended-valent PCVs in Korea, serotype 19A continued to be the most common serotype causing IPD in children. Subsequently, the proportion of 19A decreased, and non-vaccine serotypes emerged as an important cause of IPD. The impact of extended-valent vaccines must be continuously monitored.
DOI
10.3346/jkms.2016.31.7.1082
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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