Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 방은경 | * |
dc.date.accessioned | 2016-08-28T11:08:51Z | - |
dc.date.available | 2016-08-28T11:08:51Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1738-2696 | * |
dc.identifier.other | OAK-18840 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218294 | - |
dc.description.abstract | We aimed to evaluate the effects of onlay-type grafted human freeze-dried corticocancellous bone block (FDBB) and deproteinized bovine bone with collagen (DBBC) loaded with Escherichia coli-produced recombinant human bone morphogenetic protein-2 (ErhBMP-2) on space maintenance and new bone formation in rat calvaria. Collagen sponge (CS), FDBB, or DBBC disks (8x4 mm) with ErhBMP-2 (2.5 mu g) were implanted onto the calvaria of male Sprague-Dawley rats, whereas CS with buffer was implanted onto the calvaria as controls (n=20/carrier). Rats were killed at 2 or 8 weeks post-surgery for histologic and histomorphometric analyses; total augmented area, new bone area, and bone density were evaluated. At both time-points, all ErhBMP-2 groups showed significantly higher new bone area and bone density than the control group (p<0.05). ErhBMP-2/FDBB and ErhBMP-2/DBBC groups showed significantly higher total augmented area than ErhBMP-2/CS group (8 weeks), and ErhBMP-2/FDBB group showed significantly higher new bone area and bone density than ErhBMP-2/DBBC group (p<0.05). ErhBMP-2/CS group showed the highest bone density (p<0.05). Combining ErhBMP-2 with FDBB or DBBC could significantly improve onlay graft outcomes, by new bone formation and bone density increase. Moreover, onlay-grafted FDBB and DBBC with ErhBMP-2 could be an alternative to autogenous block onlay bone graft. | * |
dc.language | English | * |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | * |
dc.subject | Freeze-dried corticocancellous bone block | * |
dc.subject | Deproteinized bovine bone with collagen | * |
dc.subject | Escherichia coli-produced recombinant human bone morphogenetic protein-2 | * |
dc.subject | Onlay graft | * |
dc.subject | Space maintenance | * |
dc.subject | New bone formation | * |
dc.title | Effects of Block Bone Substitutes Loaded with Escherichia Coli-Produced Recombinant Human Bone Morphogenetic Protein-2 on Space Maintenance and Bone Formation in Rat Calvarial Onlay Model | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 311 | * |
dc.relation.lastpage | 321 | * |
dc.relation.journaltitle | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | * |
dc.identifier.doi | 10.1007/s13770-016-0011-4 | * |
dc.identifier.wosid | WOS:000377468200013 | * |
dc.identifier.scopusid | 2-s2.0-84973369737 | * |
dc.author.google | Lee, Jae-Sook | * |
dc.author.google | Jung, Gyu-Un | * |
dc.author.google | Pang, Eun-Kyoung | * |
dc.contributor.scopusid | 방은경(8058781900) | * |
dc.date.modifydate | 20231123093533 | * |