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Prenatal Exposure to Perfluorinated Compounds Affects Birth Weight Through GSTM1 Polymorphism

Title
Prenatal Exposure to Perfluorinated Compounds Affects Birth Weight Through GSTM1 Polymorphism
Authors
Kwon, Eun JinShin, Joon SooKim, Byung MiShah-Kulkarni, SurabhiPark, HyesookKho, Young LimPark, Eun AeKim, Young JuHa, Eun Hee
Ewha Authors
하은희박은애김영주박혜숙
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 박혜숙scopus
Issue Date
2016
Journal Title
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
ISSN
1076-2752JCR Link1536-5948JCR Link
Citation
vol. 58, no. 6, pp. E198 - E205
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: The aim of this study was to investigate the effect of genetic polymorphisms on the association of prenatal exposure to perfluorinated compounds (PFCs) with birth weight. Methods: We analyzed the level of eight PFCs in cord blood and two genetic polymorphisms in maternal blood of 268 subjects. Results: Concentrations of perfluorooctanoic acid, perfluorooctane sulfonate, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) showed significant association with a decrease in birth weight (P<0.05). In mothers with glutathione S-transferase M1 (GSTM1) null genotype, concentrations of PFNA, PFDA, and PFUnDA showed significantly negative association with birth weight (P<0.05). Conclusion: Our findings indicated that GSTM1 polymorphism might affect the association between exposure to PFCs and birth weight, suggesting the effect of genetic susceptibility on the relationship between prenatal PFCs exposure and birth outcomes.
DOI
10.1097/JOM.0000000000000739
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의학전문대학원 > 의학과 > Journal papers
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