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Reproductive Factors Predicting Angiographic Obstructive Coronary Artery Disease: The KoRean wOmen'S Chest Pain rEgistry (KoROSE)

Title
Reproductive Factors Predicting Angiographic Obstructive Coronary Artery Disease: The KoRean wOmen'S Chest Pain rEgistry (KoROSE)
Authors
Kim, Hack-LyoungKim, Myung-AShim, Wan-JooPark, Seong MiKim, Yong HyunNa, Jin OhShin, Mi SeungKim, Yong-JinYoon, Hyun JuShin, Gil JaCho, YunkyungKim, Sung-EunHong, Kyung-SoonCho, Kyoung Im
Ewha Authors
신길자
SCOPUS Author ID
신길자scopus
Issue Date
2016
Journal Title
JOURNAL OF WOMENS HEALTH
ISSN
1540-9996JCR Link1931-843XJCR Link
Citation
vol. 25, no. 5, pp. 443 - 448
Publisher
MARY ANN LIEBERT, INC
Indexed
SCI; SCIE; SSCI; SCOPUS WOS scopus
Abstract
Background: Whether reproductive factors are associated with coronary artery disease (CAD) has been debated. The aim of this study was to investigate etiologic associations of a wide range of reproductive factors of women with the presence of angiographic obstructive CAD. Materials and Methods: Study data were obtained from a nationwide registry that enrolled 687 Korean women (59.9 +/- 11.4 years) with chest pain undergoing invasive coronary angiography (ICA). Obstructive CAD was defined as >= 50% luminal stenosis of one or more epicardial coronary arteries in ICA. Information on reproductive history, including ages at menarche and menopause, duration of reproductive capacity, number of pregnancies, hormonal replacement therapy, and history of twin pregnancy, was obtained using a standardized questionnaire. Results: A total of 178 women (25.9%) had obstructive CAD. Multivariable logistic regression analysis identified that later age at menarche (odds ratio [OR] = 1.265, 95% confidence interval [CI] = 1.064-1.504, p = 0.008, per year) and increased number of pregnancies (OR = 1.223, 95% CI = 1.026-1.457, p = 0.025, per pregnancy) were the independent predictors of obstructive CAD even after controlling for potential confounders, including age, diabetes mellitus, hypertension, dyslipidemia, renal function, high-density lipoprotein level, white blood cell count, hemoglobin, and E/c'. Conclusions: Later age at menarche and increased number of pregnancies may be reproductive risk factors for angiographic obstructive CAD, suggesting the important role of hormonal status in the development of CAD.
DOI
10.1089/jwh.2015.5381
Appears in Collections:
의과대학 > 의학과 > Journal papers
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