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Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice

Title
Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice
Authors
Jeong, Sae ImShin, Jin A.Cho, SungheeKim, Hye WonLee, Ji YoonKang, Jihee LeePark, Eun-Mi
Ewha Authors
이지희박은미신진아
SCOPUS Author ID
이지희scopus; 박은미scopus; 신진아scopus
Issue Date
2016
Journal Title
NEUROBIOLOGY OF AGING
ISSN
0197-4580JCR Link1558-1497JCR Link
Citation
vol. 44, pp. 74 - 84
Keywords
AgingFemalesInflammationIschemic strokeResveratrolVisceral adipose tissue
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Resveratrol is known to improve metabolic dysfunction associated with obesity. Visceral obesity is a sign of aging and is considered a risk factor for ischemic stroke. In this study, we investigated the effects of resveratrol on inflammation in visceral adipose tissue and the brain and its effects on ischemic brain injury in aged female mice. Mice treated with resveratrol (0.1 mg/kg, p.o.) for 10 days showed reduced levels of interleukin-1 beta and tumor necrosis factor-alpha, as well as a reduction in the size of adipocytes in visceral adipose tissue. Resveratrol also reduced interleukin-1 beta and tumor necrosis factor-alpha protein levels and immunoglobulin G extravasation in the brain. Mice treated with resveratrol demonstrated smaller infarct size, improved neurological function, and blunted peripheral inflammation at 3 days postischemic stroke. These results showed that resveratrol counteracted inflammation in visceral adipose tissue and in the brain and reduced stroke-induced brain injury and peripheral inflammation in aged female mice. Therefore, resveratrol administration can be a valuable strategy for the prevention of age-associated and disease-provoked inflammation in postmenopausal women. (C) 2016 Elsevier Inc. All rights reserved.
DOI
10.1016/j.neurobiolaging.2016.04.007
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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