Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 주웅 | - |
dc.date.accessioned | 2016-08-27T04:08:14Z | - |
dc.date.available | 2016-08-27T04:08:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1048-891X | - |
dc.identifier.issn | 1525-1438 | - |
dc.identifier.other | OAK-18639 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218239 | - |
dc.description.abstract | Objective: The aim of the study was to evaluate the efficacy of the levonorgestrel intrauterine system (LNG-IUS) for treatment of endometrial hyperplasia (EH). Methods: A prospective multicenter study was conducted from November 2010 to March 2014. Patients with histologically confirmed EH were treated with LNG-IUS. At 3, 6, and 9 months after LNG-IUS insertion, follow-up endometrial aspiration biopsies with the LNG-IUS in the uterus were undertaken. At the 12th month of follow-up, endometrial tissues were obtained via 2 methods: endometrial aspiration biopsy with the LNG-IUS in the uterus, followed by dilatation and curettage (D&C) after LNG-IUS removal. The primary outcome was the regression rate at 12 months after LNG-IUS insertion, and the secondary outcome was the consistency of the results between the endometrial aspiration biopsy and the D&C. Results: The study population comprised 75 patients, including 37 with simple hyperplasia without atypia; 3 with atypical simple hyperplasia; 23 with complex hyperplasia without atypia, and 12 with atypical complex hyperplasia. Of these patients treated with the LNGIUS, 38 (50.7%) were followed up at 12 months after LNG-IUS insertion. The complete regression rate at 12 months was 94.7% (36/38): 100% (6/6) of patients with atypical EH and 93.7% (30/32) with EH without atypia. In all of the cases (100%, 36/36), patients achieved complete regression within 3 months of LNG-IUS insertion. A comparison of the pathologic results from endometrial aspiration biopsy and D&C was carried out for 15 patients. In the histologic results by endometrial aspiration biopsy, 14 patients were diagnosed as "normal endometrium" and 1 as "insufficient tissue for pathologic evaluation." Among the 14 cases of normal endometrium by endometrial aspiration biopsy, 1 was diagnosed as "residual EH" by D&C, and the 1 case with insufficient tissue was diagnosed as normal endometrium by D&C. Conclusions: Levonorgestrel intrauterine system is an effective and favorable method for treatment of EH. | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & | - |
dc.publisher | WILKINS | - |
dc.subject | Endometrial hyperplasia | - |
dc.subject | Progesterone | - |
dc.subject | LNG-IUS | - |
dc.subject | Dilatation and curettage | - |
dc.subject | Endometrial aspiration biopsy | - |
dc.title | Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System A Korean Gynecologic-Oncology Group Study | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 26 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 711 | - |
dc.relation.lastpage | 715 | - |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | - |
dc.identifier.doi | 10.1097/IGC.0000000000000669 | - |
dc.identifier.wosid | WOS:000377146600016 | - |
dc.identifier.scopusid | 2-s2.0-84965179403 | - |
dc.author.google | Kim, Mi Kyoung | - |
dc.author.google | Seong, Seok Ju | - |
dc.author.google | Kim, Jae-Weon | - |
dc.author.google | Jeon, Seob | - |
dc.author.google | Choi, Ho Sun | - |
dc.author.google | Lee, In-Ho | - |
dc.author.google | Lee, Jong Hak | - |
dc.author.google | Ju, Woong | - |
dc.author.google | Song, Eun Seop | - |
dc.author.google | Park, Hyun | - |
dc.author.google | Ryu, Hee-Sug | - |
dc.author.google | Lee, Chulmin | - |
dc.author.google | Kang, Soon-Beom | - |
dc.contributor.scopusid | 주웅(8873659700) | - |
dc.date.modifydate | 20230208112101 | - |