View : 38 Download: 0

Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial

Title
Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial
Authors
Jeon, YujinKim, BinnaKim, Jieun E.Kim, Bori R.Ban, SoonhyunJeong, Jee HyangKwon, OranRhie, Sandy JeongAhn, Chang-WonKim, Jong-HoonJung, Sung UgPark, Soo-HyunLyoo, In KyoonYoon, Sujung
Ewha Authors
정지향권오란김지은이정연류인균윤수정전유진
SCOPUS Author ID
정지향scopus; 권오란scopus; 김지은scopus; 이정연scopus; 류인균scopus; 윤수정scopus; 전유진scopus
Issue Date
2016
Journal Title
AMERICAN JOURNAL OF CHINESE MEDICINE
ISSN
0192-415XJCR Link1793-6853JCR Link
Citation
vol. 44, no. 3, pp. 489 - 514
Keywords
Subjective Cognitive ImpairmentGangliosideDeer Bone ExtractWorking MemoryDefault Mode Network
Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
This randomized, double-blind, placebo-controlled trial examined whether the administration of ganglioside, an active ingredient of deer bone extract, can improve working memory performance by increasing gray matter volume and functional connectivity in the default mode network (DMN) in individuals with subjective cognitive impairment. Seventy-five individuals with subjective cognitive impairment were chosen to receive either ganglioside (330 mu g/day or 660 mu g/day) or a placebo for 8 weeks. Changes in working memory performance with treatment of either ganglioside or placebo were assessed as cognitive outcome measures. Using voxel-based morphometry and functional connectivity analyses, changes in gray matter volume and functional connectivity in the DMN were also assessed as brain outcome measures. Improvement in working memory performance was greater in the ganglioside group than in the placebo group. The ganglioside group, relative to the placebo group, showed greater increases in gray matter volume and functional connectivity in the DMN. A significant relationship between increased functional connectivity of the precuneus and improved working memory performance was observed in the ganglioside group. The current findings suggest that ganglioside has cognitive-enhancing effects in individuals with subjective cognitive impairment. Ganglioside-induced increases in gray matter volume and functional connectivity in the DMN may partly be responsible for the potential nootropic effects of ganglioside.
DOI
10.1142/S0192415X16500270
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE