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Compositional Analysis of Walnut Lipid Extracts and Properties as an Anti-cancer Stem Cell Regulator via Suppression of the Self-renewal Capacity

Title
Compositional Analysis of Walnut Lipid Extracts and Properties as an Anti-cancer Stem Cell Regulator via Suppression of the Self-renewal Capacity
Authors
Chung, JooyeonKim, Yoo-SunLee, JisooLee, Jae HwanChoi, Sang-WoonKim, Yuri
Ewha Authors
김유리
SCOPUS Author ID
김유리scopus
Issue Date
2016
Journal Title
FOOD SCIENCE AND BIOTECHNOLOGY
ISSN
1226-7708JCR Link2092-6456JCR Link
Citation
vol. 25, no. 2, pp. 623 - 629
Keywords
walnut lipid extractcolon cancercancer stem cellself-renewal capacity
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Colon cancer is a leading cause of cancer-related deaths worldwide. Effects of walnut (Juglans regia L.) lipid extracts (WLEs) on the self-renewal capacity of cancer stem cells (CSCs) in colon cancer were investigated. The dominant component of WLEs was alpha-linoleic acid (64.6%), followed by a-linolenic acid (14.6%), and oleic acid (12.6%). A higher concentration of gamma-tocopherol (37.1%) was also present than of alpha-tocopherol (0.6%). CD133(+)CD44(+)CSCs treated with WLEs showed inhibition of colony formation and sphere formation, indicating a decrease in the self-renewal capacity. Treatment with WLEs also resulted in down-regulation of protein levels, including Notch1, phospho-GSK3 beta (p-GSK3 beta), and beta-catenin, which are associated with CSCs and the self-renewing capacity. WLEs rich in essential fatty acids and gamma-tocopherol can exert therapeutic actions on colon cancer via targeting of CSCs.
DOI
10.1007/s10068-016-0087-6
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신산업융합대학 > 식품영양학과 > Journal papers
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