View : 25 Download: 0

The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea

Title
The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea
Authors
Lee, Ho SupMin, Chang-KiLee, Je-JungKim, KihyunKim, Seok JinYoon, Dok HyunEom, Hyeon-SeokLee, HyewonLee, Won SikShin, Ho-JinLee, Ji HyunPark, YongJo, Jae-CheolDo, Young RokMun, Yeung-ChulLee, Mark HongKorean Multiple Myeloma Working
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2016
Journal Title
ANNALS OF HEMATOLOGY
ISSN
0939-5555JCR Link1432-0584JCR Link
Citation
vol. 95, no. 6, pp. 911 - 919
Keywords
Multiple myelomaThalidomideTransplantationMaintenanceSurvival
Publisher
SPRINGER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In real clinical settings (not clinical trials), thalidomide has been accepted as maintenance therapy to patients with multiple myeloma (MM) because of the cost of drugs, the limitations of medical insurance, etc., in our country (South Korea). The purpose of this study was to evaluate the utility of thalidomide maintenance for improving survival in transplantation-eligible patients with MM in the real clinical field. Differences in survival rates were estimated in patients treated with or without thalidomide maintenance. The 3-year progression-free survival rates (PFS) of patients with and without maintenance, respectively, were 55.4 and 37.2 % (p = 0.005). The 3-year overall survival rates (OS) were 88.0 and 84.0 % (p = 0.105). No difference in 3-year OS after relapse or progression (OS2) was observed between the two groups (50.4 and 55.3 %, p = 0.661). The 3-year PFS of patients with and without maintenance therapy who had shown less than CR after ASCT were 68.4 and 23.3 % (p < 0.001). In conclusion, Thalidomide maintenance therapy showed longer PFS in real clinical practice, and long-term use of thalidomide did not interfere with the efficacy of salvage chemotherapy in patients who experienced progression or relapse after ASCT. In addition, thalidomide maintenance might be also useful for patients who have shown less than CR after ASCT.
DOI
10.1007/s00277-016-2660-8
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE