View : 26 Download: 0

Impact of the multiplex polymerase chain reaction in culture-positive samples on appropriate antibiotic use in patients with staphylococcal bacteremia

Title
Impact of the multiplex polymerase chain reaction in culture-positive samples on appropriate antibiotic use in patients with staphylococcal bacteremia
Authors
Na, Sun HeeKim, Chung JongKim, MoonsukPark, Jeong SuSong, Kyoung-HoChoe, Pyoeng GyunPark, Wan BeomBang, Ji-HwanKim, Eu SukPark, Sang WonPark, Kyoung UnKim, Nam JoongOh, Myoung-donKim, Hong Bin
Ewha Authors
김충종
SCOPUS Author ID
김충종scopus
Issue Date
2016
Journal Title
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
ISSN
0732-8893JCR Link1879-0070JCR Link
Citation
vol. 84, no. 4, pp. 353 - 357
Keywords
Staphylococcus aureusBacteremiaMultiplex polymerase chain reaction
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Rapid identification of the microorganisms in patients with bacteremia may be useful in clinical practice. We evaluated the impact of the multiplex polymerase chain reaction (PCR) on appropriate antibiotic use for patients with gram-positive cocci cluster (GPCC) bacteremia. We divided the GPCC bacteremia cases into a pre-PCR group (2010-2011) and a post-PCR group (2012-2013). A total 664 cases were included in the pre-PCR group; and 570, in the post-PCR group. In methicillin-susceptible Staphylococcus aureus (MSSA) cases, optimal antibiotics were administered earlier in the post-PCR group (77.4 h versus 42.6 h, P = 0.035). Although the proportions of glycopeptide exposure did not differ (54.7% versus 56.7%, P = 0.799), the duration of exposure decreased (69.6 h versus 30.7 h, P = 0.004). In methicillin-resistant S. aureus cases, the time to optimal antibiotics administration did not differ (45.4 h versus 43.7 h, P = 0275). Multiplex PCR test significantly improved the early initiation of optimal antibiotics in MSSA bacteremia and reduced the unnecessary glycopeptide exposure. (C) 2016 Elsevier Inc. All rights reserved.
DOI
10.1016/j.diagmicrobio.2015.12.007
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE