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Current trend in translational research for treatment of ovarian cancer

Title
Current trend in translational research for treatment of ovarian cancer
Authors
Ju, Woong
Ewha Authors
주웅
SCOPUS Author ID
주웅scopus
Issue Date
2016
Journal Title
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
ISSN
1975-8456JCR Link2093-5951JCR Link
Citation
vol. 59, no. 3, pp. 189 - 193
Keywords
Ovarian neoplasmsTranslational medical researchCompanion diagnostics
Publisher
KOREAN MEDICAL ASSOC
Indexed
SCOPUS; KCI WOS scopus
Abstract
Ovarian cancer is the most lethal gynecologic cancer. Countless efforts have been made to improve the survival of ovarian cancer patients by clinicians as well as basic researchers so far. As a result of those extensive translational researches some of promising molecular targets and its proper therapies are introduced into practice for treating intractable ovarian cancer, which includes anti-angiogenic therapy, tyrosine kinase inhibitor, and other modulators of cancer-related signaling pathways. Current trend of translational researches in ovarian cancer treatment are mainly focused on discovering companion diagnostics which can categorize the subgroup of patient having specific biomarker that may serve as a target of new treatment because the consequent outcome of new therapy varies depending on the molecular profile of each patient. It is important for clinician to consider each ovarian cancer patients to have a possible therapeutic target and to examine the tissue biopsies with available companion diagnostics. In addition more interest and endeavor should be given to the clinical trials to apply the result of up-to-date translational researches.
DOI
10.5124/jkma.2016.59.3.189
Appears in Collections:
의과대학 > 의학과 > Journal papers
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