Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shunichi Fukuzumi | * |
dc.contributor.author | Kei Okubo | * |
dc.date.accessioned | 2016-08-27T04:08:06Z | - |
dc.date.available | 2016-08-27T04:08:06Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1043-1802 | * |
dc.identifier.other | OAK-18417 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218158 | - |
dc.description.abstract | Herein we report the syntheses and comparative photophysical, electrochemical, in vitro, and in vivo biological efficacy of 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-cyanine dye (HPPH-CD) and the corresponding indium (In), gallium (Ga), and palladium (Pd) conjugates. The insertion of a heavy metal in the HPPH moiety makes a significant difference in FRET (Forster resonance energy transfer) and electrochemical properties, which correlates with singlet oxygen production [a key cytotoxic agent for photodynamic therapy (PDT)] and long-term in vivo PDT efficacy. Among the metalated analogs, the In(III) HPPH-CD showed the best cancer imaging and PDT efficacy. Interestingly, in contrast to free base HPPH-CD, which requires a significantly higher therapeutic dose (2.5 ymol/kg) than imaging dose (0.3 ymol/kg), the corresponding In(III) HPPH-CD showed excellent imaging and therapeutic potential at a remarkably low dose (0.3 itmol/kg) in BALB/c mice bearing Colon26 tumors. A comparative study of metalated and corresponding nonmetalated conjugates further confirmed that STAT-3 dimerization can be used as a biomarker for determining the level of photoreaction and tumor response. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Effect of Metalation on Porphyrin-Based Bifunctional Agents in Tumor Imaging and Photodynamic Therapy | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 667 | * |
dc.relation.lastpage | 680 | * |
dc.relation.journaltitle | BIOCONJUGATE CHEMISTRY | * |
dc.identifier.doi | 10.1021/acs.bioconjchem.5b00656 | * |
dc.identifier.wosid | WOS:000372478600021 | * |
dc.identifier.scopusid | 2-s2.0-84962230659 | * |
dc.author.google | Patel, Nayan J. | * |
dc.author.google | Chen, Yihui | * |
dc.author.google | Joshi, Penny | * |
dc.author.google | Pera, Paula | * |
dc.author.google | Baumann, Heinz | * |
dc.author.google | Missert, Joseph R. | * |
dc.author.google | Ohkubo, Kei | * |
dc.author.google | Fukuzumi, Shunichi | * |
dc.author.google | Nani, Roger R. | * |
dc.author.google | Schnermann, Martin J. | * |
dc.author.google | Chen, Ping | * |
dc.author.google | Zhu, Jialiang | * |
dc.author.google | Kadish, Karl M. | * |
dc.author.google | Pandey, Ravindra K. | * |
dc.contributor.scopusid | Shunichi Fukuzumi(35430038100;58409757400) | * |
dc.contributor.scopusid | Kei Okubo(7101788990) | * |
dc.date.modifydate | 20240401081001 | * |